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221 Spelling Bee

Affect: To produce a material influence
upon or alteration in, or to act upon a person so as to produce a response. “As Detective Inspector, Gregory Lestrade affects many people and outcomes.“

Effect: Something that inevitably follows a cause or agent. A distinctive impression, or the creation of such. “Gregory Lestrade’s air of command and competence has great effect upon Mycroft Holmes.”

Mnemonic device for the above: The affect is the action, while the effect is the result.

Effect #2: To cause to come into being, such as by putting something into operation, or bringing something about, often by overcoming obstacles. “Mycroft Holmes effects change…globally.”